Fri Jun 10 2022

84 articles - From Friday Jun 03 2022 to Friday Jun 10 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Gastrointest Endosc

Interventions to improve adenoma detection rates for colonoscopy.

Pubmed   Journal   ReadQx 

Interventions to improve the performance of upper GI endoscopy quality indicators.

To date, data on interventions aimed to improve these indicators are scarce. We systematically reviewed the literature to identify interventions and measures demonstrated to improve the performance of previously established upper endoscopy quality indicators. We also identified evidence gaps and opportunities for improvement in this area.

Pubmed   Journal   ReadQx 

Gut

Nomenclature and diagnosis of seronegative coeliac disease and chronic non-coeliac enteropathies in adults: the Paris consensus.

This paper describes the Paris consensus on the definitions and diagnostic criteria for seronegative CD and chronic NCEs in adults.

Pubmed   Journal   ReadQx 

J Hepatol

EASL Clinical Practice Guidelines on haemochromatosis.

The stage of liver fibrosis and other end-organ damage should be carefully assessed at diagnosis because they determine disease management. Patients with advanced fibrosis should be included in a screening programme for hepatocellular carcinoma. Treatment targets for phlebotomy are ferritin <50 µg/L during the induction phase and <100 µg/L during the maintenance phase.

Pubmed   Journal   ReadQx 


Meta-analysis

meta-analyses and systematic reviews

Endoscopy

THE ROLE OF PANCREATOSCOPY IN THE DIAGNOSTIC WORK-UP OF INTRA-DUCTAL PAPILLARY MUCINOUS NEOPLASMS: A SYSTEMATIC REVIEW AND META ANALYSIS.

POP is technically successful in the vast majority of patients with (suspected) IPMN, has a considerably high diagnostic accuracy, but an adverse event rate of 12%. Data on intraoperative pancreatoscopy is scarce, but small studies suggest its use can alter surgical management. Future studies are needed to better define the role of POP in the diagnostic work-up of IPMN.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Clip Closure to Prevent Adverse Events Following Endoscopic Mucosal Resection of Proximal Large Non-pedunculated Colorectal Polyps: Meta-analysis of Individual Patient Data from Randomized Controlled Trials.

Prophylactic clipping is efficacious in preventing CSPEB after EMR of proximal LNPCPs. Therefore, clip closure should be considered a standard component of EMR of LNPCPs in the proximal colon.

Pubmed   Journal   ReadQx 

J Crohns Colitis

Faecal metabolomics in paediatric inflammatory bowel disease: a systematic review.

This systematic review provides evidence for distinct faecal metabolomic profiles in paediatric IBD. However, results varied across studies, possibly due to differences in study design and applied analytical techniques. Faecal metabolomics could provide more insight into host-microbial interactions in IBD, but further studies with standardised methodologies and reporting are needed.

Pubmed   Journal   ReadQx 

J Hepatol

Carvedilol reduces the risk of decompensation and mortality in patients with compensated cirrhosis in a competing-risk meta-analysis.

Long-term carvedilol therapy reduced decompensation of cirrhosis and significantly improved survival in compensated patients with CSPH. This suggests that screening patients with compensated cirrhosis for CSPH to start therapy with carvedilol can improve outcomes.

Pubmed   Journal   ReadQx 

Neurogastroenterol Motil

Normative values for esophageal functional lumen imaging probe measurements: A meta-analysis.

Given these observations, we recommend using a cut-off of 2mm 2 /mmHg for clinical practice, values below can be considered abnormal. Given that 5.4% of the healthy subjects will have an EGJ-DI below 2mm 2 /mmHg at 40ml, we recommend using the 50 and 60ml distention volumes. The clinical use of an upper limit for normality of EGJ-DI seems questionable.

Pubmed   Journal   ReadQx 


Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Clinical trial: a controlled trial of baclofen add-on therapy in PPI-refractory gastro-oesophageal reflux symptoms.

Baclofen decreases several reflux parameters in PPI refractory GERD symptoms, but pH-impedance monitoring is necessary before treatment as only SAP+ patients experience clinical benefit after 4weeks.

Pubmed   Journal   ReadQx 

Clinical trial: seven-day vonoprazan- versus 14-day proton pump inhibitor-based triple therapy for first-line Helicobacter pylori eradication.

One-week vonoprazan-based triple therapy achieved comparable efficacy to 2-week PPI-based triple therapy and was well tolerated.

Pubmed   Journal   ReadQx 

Home-based, tunnelled peritoneal drainage system as an alternative treatment option for patients with refractory ascites.

The implant of PeCa allows home-based therapy of RA in patients with liver cirrhosis and contraindication for TIPS. However, the risk for complications such as AKI or hyponatraemia has to be considered and prospective studies are needed.

Pubmed   Journal   ReadQx 

Serological biomarkers of type I, III and IV collagen turnover are associated with the presence and future progression of stricturing and penetrating Crohn's disease.

Elevated degradation of type I, III and IV collagen and excessive (relative) formation of type IV collagen strongly associates with stricturing CD. Type I and IV collagen fragments show predictive potential for the risk of penetrating disease progression. These biomarkers may become valuable tools for detection and prediction of stricturing and penetrating CD.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Admixture mapping in African Americans identifies new risk loci for HCV-related cirrhosis.

We used admixture mapping to identify novel genomic regions on 2q21.1 and 6p21.2 that may be associated with HCV-related cirrhosis risk in African Americans.

Pubmed   Journal   ReadQx 

Poor diagnostic efficacy of noninvasive tests for advanced fibrosis in obese or younger than 60 diabetic NAFLD patients.

Pubmed   Journal   ReadQx 

Endoscopy

Bite-on-bite biopsies for the detection of residual esophageal cancer after neoadjuvant chemoradiotherapy.

A second (bite-on-bite) biopsy improves the detection of residual esophageal cancer by almost 20 percentage points, at the expense of increasing the false-positive rate by 3 percentage points. The higher detection rate is explained by the higher number of biopsies obtained rather than by the penetration depth.

Pubmed   Journal   ReadQx 

Digital single operator pancreatoscopy for the treatment of symptomatic pancreatic duct stones. A prospective multicenter cohort trial.

DSOP guided endotherapy is effective and safe for treatment of symptomatic MPD stones in highly selected patients with CP. It significantly reduces pain and could be considered as an alternative to standard ERCP techniques for MPD stone treatment in these patients.

Pubmed   Journal   ReadQx 

What size cutoff level should be used to implement optical polyp diagnosis?

Surveillance interval agreements between pathology and optical diagnosis for the three groups were 97.2%, 95.5%, and 94.2%, respectively. Total reductions in pathology examinations for the three groups were 33.5%, 62.3%, and 78.2%, respectively. CONCLUSION : A 3-mm cutoff for clinical implementation of optical diagnosis resulted in a very low risk of delayed management of advanced neoplasia while showing high surveillance interval agreement with pathology and a one-third reduction in overall requirement for pathology examinations.

Pubmed   Journal   ReadQx 

Gastroenterology

Metabolome changes with diet-induced remission in pediatric Crohn's disease.

CDED+PEN- and EEN-induced remission are associated with significant changes in IBD-associated metabolites such as kynurenine, ceramides, amino acids and others. Sustained remission with CDED+PEN, but not EEN, was associated with persistent changes in metabolites. ClincialTrials.gov number, NCT01728870.

Pubmed   Journal   ReadQx 

The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality in 2020 and projections to 2040: New estimates from GLOBOCAN 2020.

These updated estimates of the global burden of esophageal cancer represent an important baseline for setting priorities in policymaking and developing and accelerating cancer control initiatives to reduce the current and projected burden. While primary prevention continues to remain key, screening and early detection represent important components of esophageal cancer control in high-risk populations.

Pubmed   Journal   ReadQx 

Uncovering 1,058 novel human enteric DNA viruses through deep long-read third-generation sequencing and their clinical impact.

We uncovered 1,058 novel human gut viruses. These findings can contribute to clinical diagnosis, current viral reference genome and future virome investigation.

Pubmed   Journal   ReadQx 

Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the US and Europe: Randomized Clinical Trial.

Both vonoprazan-based regimens were superior to PPI-based triple therapy in clarithromycin-resistant strains and in the overall study population. ; NCT04167670.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Aerosol and droplet generation in upper and lower gastrointestinal endoscopy: whole procedure and event-based analysis.

Gastrointestinal endoscopy performed via the mouth, nose or rectum al generates significant quantities of aerosols and droplets. As the infectivity of procedures is not established, we therefore suggest adequate PPE is used for al GI endoscopy where there is a high population prevalence of COVID-19. Avoiding throat and nasal spray would significantly reduce particles generated from UGI procedures.

Pubmed   Journal   ReadQx 

Impact of endobiliary radiofrequency ablation on biliary drainage in patients with malignant biliary strictures treated with uncovered self-expandable metal stents: a randomized controlled multicenter-trial.

RFA as an addition to SEMS-implantation had no positive impact on patency rate or survival.

Pubmed   Journal   ReadQx 

Submucosal tunneling endoscopic septum division for esophageal diverticulum with a median follow-up of 39 months: a multicenter cohort study.

STESD is a safe and valid endoscopic minimally invasive surgery for esophageal diverticulum, which can reduce symptoms and improve quality of life.

Pubmed   Journal   ReadQx 

Hepatology

Access to Technology to Support Telehealth in Areas without Specialty Care for Liver Disease.

Areas with poor access to liver disease specialty care have a greater burden of liver-related mortality, and many of their residents lack access to technology. Therefore, a telehealth strategy based solely on patient device ownership and internet access will exclude a large proportion of individuals in the areas of highest need. Further work should be done at the local and state levels to design optimal strategies to reach their populations of need.

Pubmed   Journal   ReadQx 

Inflamm Bowel Dis

David Against Goliath: Direct Comparison of Handheld Bowel Sonography and Magnetic Resonance Enterography for Diagnosis of Crohn's Disease.

Handheld bowel sonography and MRE are 2 accurate and noninvasive procedures for diagnosis of CD, although MRE is more sensitive in defining extension, location, and complications. Handheld bowel sonography could be used as effective ambulatory (or out-of-office) screening tool for identifying patients to refer for MRE examination due to high probability of CD diagnosis.

Pubmed   Journal   ReadQx 

Feasibility of a Clinical Decision Support Tool for Ustekinumab to Predict Clinical Remission and Relapse in Patients With Crohn's Disease: A Multicenter Observational Study.

The UST-CDST can predict clinical relapse in patients with moderate to severe CD subjected to ustekinumab therapy.

Pubmed   Journal   ReadQx 

Identifying the Presence, Activity, and Status of Extraintestinal Manifestations of Inflammatory Bowel Disease Using Natural Language Processing of Clinical Notes.

NLP methods can both detect and infer the activity status of EIMs using the medical document an information source. Though source document variation and ambiguity present challenges, NLP offers exciting possibilities for population-based research and decision support in IBD.

Pubmed   Journal   ReadQx 

Mindfulness Intervention Decreases Frequency and Severity of Flares in Inactive Ulcerative Colitis Patients: Results of a Phase II, Randomized, Placebo-Controlled Trial.

MIs could be considered as adjuvant treatment for a subset of UC patients with high perceived stress and low state of mindfulness.The trial was registered at clinicaltrials.gov as NCT01491997.

Pubmed   Journal   ReadQx 

J Crohns Colitis

Targeted Assessment of Mucosal Immune Gene Expression Predicts Clinical Outcomes in Children with Ulcerative Colitis.

Targeted assessment of rectal mucosal immune gene expression predicts 52-week CSFR in treatment-naïve pediatric UC patients. Further exploration of IL-13R2 as a therapeutic target in UC, and future studies of the epithelial-specific role of RORC in UC pathogenesis are warranted.

Pubmed   Journal   ReadQx 

Neurogastroenterol Motil

Gene expression and clinical outcomes after dietary treatment: A prospective study.

These findings strongly suggest that elimination diets, besides a clinical and histological response, are associated with a broad transcriptional response at the level of the esophageal epithelium.

Pubmed   Journal   ReadQx 

Normative values of intra-bolus pressure and esophageal compliance based on 4D high-resolution impedance manometry.

4D-HRIM provides a standardized methodology to track the nadir impedance and provide measurements of IBP during maximal distention across phases 1-3 of bolus transit. Median IBP and delta IBP were different across the phases, supporting the need to define IBP by phase. Additionally, the EGJ-DI calculated during phase 3 was similar to the 60-ml EGJ-DI from FLIP in the same subjects suggesting that 4D-HRIM can quantify EGJ opening during primary peristalsis.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Diagnostic and therapeutic approach to persistent abdominal pain beyond irritable bowel syndrome.

Persistent abdominal pain (PAP) is a challenging condition to diagnose and treat. Many patients undergo repeated diagnostic testing and treatment, including surgery, without achieving symptom relief. Increasing physician awareness of the various causes of PAP, especially of rare diseases that are less well known, may improve patient outcomes.

Pubmed   Journal   ReadQx 

Review: Vascular effects of PPARs in the context of NASH.

Aim This review summarises and discusses the pathobiological role of PPARs in cardiovascular diseases with a special focus on their impact and therapeutic potential in NAFLD and NASH. Results and conclusions PPARs may be attractive for the treatment of NASH due to their liver-specific effects but also because of their efficacy in improving cardiovascular outcomes, which may later impact liver disease. Assessment of cardiovascular disease in the context of NASH trials is, therefore, of the utmost importance, both from a safety and efficacy perspective.

Pubmed   Journal   ReadQx 

Gastroenterology

Arid1a: A Gatekeeper in the Development of Pancreatic Cancer From a Rare Precursor Lesion.

Pubmed   Journal   ReadQx 

Can We Predict the Onset of Celiac Disease?

Pubmed   Journal   ReadQx 

Rear Window-What Can the Gut Tell Us About Long-COVID?

Pubmed   Journal   ReadQx   PMC

ß-catenin is a novel target in YAP-driven cholangiocarcinoma.

Pubmed   Journal   ReadQx 

The influence of place and geography on outcomes across the cancer continuum.

Pubmed   Journal   ReadQx 

Gastrointest Endosc

Robotics in Therapeutic Endoscopy: Where We Are and Where Are We Going? (with video).

The incorporation of robotics in gastroenterology initially aimed to address shortcomings of flexible endoscopes in natural orifice transluminal endoscopy. Developing therapeutic endoscopic robotic platforms now offer operators improved ergonomics, visualization, dexterity, precision, and control and the possibility of increasing proficiency and standardization of complex endoscopic procedures including endoscopic submucosal dissection, endoscopic full thickness resection, and endoscopic suturing. The following review discusses the history, potential applications, and tools that are currently available and in development for robotics in therapeutic endoscopy.

Pubmed   Journal   ReadQx 

Hepatology

Rethinking the management of pain in cirrhosis: toward precision therapy for pain.

However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as GI bleeding, renal injury, falls, and hepatic encephalopathy. Chronic pain can be categorized mechanistically into three pain types: nociceptive, neuropathic, and nociplastic, each responsive to different therapies. By discussing the identification, etiology, and treatment of these three mechanistic pain descriptors with a focus on specific challenges in patients with cirrhosis, we provide a framework for better tailoring treatments, including non-pharmacologic therapies, to patients' needs.

Pubmed   Journal   ReadQx 

The role of TIPS in patients with cirrhosis and ascites: recent evolution and open questions.

The combination of these factors is important to guide clinical decision making and identify the best strategy for each individual patient. There is still a need to identify the best timing for TIPS placement in the natural history of ascites (recurrent vs refractory) as well as which type and level of renal dysfunction is acceptable when TIPS is proposed for the treatment of ascites in cirrhosis. Future studies are needed to define the optimal stent diameter according to patient characteristics and individual risk of shunt-related side-effects, particularly hepatic encephalopathy and insufficient cardiac response to hemodynamic consequences of TIPS insertion.

Pubmed   Journal   ReadQx 

Inflamm Bowel Dis

Impact of SARS-CoV-2 Vaccination on Inflammatory Bowel Disease Activity and Development of Vaccine-Related Adverse Events: A Survey From China.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Clin Gastroenterol Hepatol

Biomarkers of liver fibrosis may behave differently depending on associated co-morbidities: need to consider the context of use.

Pubmed   Journal   ReadQx 

Reply to "Discrepancy between NAFLD and MAFLD - is it only due to misclassification of MAFLD?"

Pubmed   Journal   ReadQx 

Telemonitoring and the new era of home-based care in hepatology.

Pubmed   Journal   ReadQx 

Gastroenterology

Controversy of Preoperative Exposure to Tumor Necrosis Factor Inhibitors in Surgical and Infectious Complications of Inflammatory Bowel Disease.

Pubmed   Journal   ReadQx 

Gut

Correspondence on "PICaSSO Histologic Remission Index (PHRI) in ulcerative colitis: development of a novel simplified histological score for monitoring mucosal healing and predicting clinical outcomes and its applicability in an artificial intelligence system" by Gui et al.

Pubmed   Journal   ReadQx 

Great escape: how infectious SARS-CoV-2 avoids inactivation by gastric acidity and intestinal bile.

Pubmed   Journal   ReadQx 

Maternal antibiotic exposure during pregnancy and risk of IBD in offspring: a population-based cohort study.

Pubmed   Journal   ReadQx 

Inflamm Bowel Dis

COVID-19 as a Trigger for De Novo Crohn's Disease.

Pubmed   Journal   ReadQx   PMC


Others

all remaining publications eg case reports, images of the month, etc…

Am J Gastroenterol

Calendar of Courses, Symposiums and Conferences.

Pubmed   Journal   ReadQx 

Correction to: Demystifying Esophageal Lichen Planus: A Comprehensive Review of a Rare Disease You Will See in Practice.

Pubmed   Journal   ReadQx 

Response to Chang et al.

Pubmed   Journal   ReadQx 

Response to Swami et al.

Pubmed   Journal   ReadQx 

Tibetan Ethnicity, Birthplace, Helicobacter pylori Infection, and Gastric Cancer Risk.

Pubmed   Journal   ReadQx 

Clin Gastroenterol Hepatol

Transient Uterine Prolapse: A Rare Complication of Endoscopic Polypectomy.

Pubmed   Journal   ReadQx 

Waist circumference and insulin resistance are the most predictive metabolic factors for steatosis and fibrosis.

Pubmed   Journal   ReadQx 

Endoscopy

Centralized care for the management of Barrett's esophagus: the path forward or just an academic dream?

Pubmed   Journal   ReadQx 

Endoscopy-guided pharyngoesophageal stent fixation after total laryngectomy.

Pubmed   Journal   ReadQx 

Forward-viewing echoendoscope plus gel immersion technique in a patient with Billroth II reconstruction.

Pubmed   Journal   ReadQx 

Hybrid peroral endoscopic myotomy for large Zenker's diverticulum.

Pubmed   Journal   ReadQx 

Innovative endoscopic submucosal dissection for early gastric neoplasm using intralesional traction and snaring techniques.

Pubmed   Journal   ReadQx 

Per anal endoscopic myectomy for rectal neuroendocrine tumor invading submucosal deep layer and ending at the muscle layer.

Pubmed   Journal   ReadQx 

Post-polypectomy surveillance: walking in the fog.

Pubmed   Journal   ReadQx 

Successful removal of an uncovered metallic stent using peroral direct cholangioscopy and the stent-in-stent technique.

Pubmed   Journal   ReadQx 

Gastroenterology

A MULTICENTER RANDOMIZED CONTROLLED TRIAL OF SURVEILLANCE VERSUS ENDOSCOPIC THERAPY FOR BARRETT'S ESOPHAGUS WITH LOW-GRADE DYSPLASIA: THE SURVENT TRIAL STUDY RATIONALE, METHODOLOGY, INNOVATION AND IMPLICATIONS.

Pubmed   Journal   ReadQx 

A Trapped Colon.

Pubmed   Journal   ReadQx 

An 80-Year-Old Man with Hematochezia and Hyperkalemia.

Pubmed   Journal   ReadQx 

An unusual complication of endoscopic cyanoacrylate Injection for gastric varix.

Pubmed   Journal   ReadQx 

Analysis of Age, Race, Ethnicity, and Sex of Participants in Clinical Trials Focused on Disorders of Gut-Brain Interaction.

Pubmed   Journal   ReadQx 

Bile duct stricture at the superior margin of pancreas.

Pubmed   Journal   ReadQx 

Food Insecurity in Digestive Diseases.

Pubmed   Journal   ReadQx 

Hide and Seek - Dysplasia Camouflage in a Patient with Barrett's Esophagus.

Pubmed   Journal   ReadQx 

Mucus sialyation maintains the peace in intestinal host microbe relations.

Pubmed   Journal   ReadQx 

Prolonging survival in advanced esophageal squamous cell carcinoma with immune checkpoint inhibitors.

Pubmed   Journal   ReadQx 

Rate of autoactivation determines pancreatitis phenotype in trypsinogen mutant mice.

Pubmed   Journal   ReadQx 

Splitting hairs: Folliculin parts the good from the bad in mTORC1 control over lipid metabolism.

Pubmed   Journal   ReadQx 

Target sign and abdominal pain, an approach to diagnosis and treatment.

Pubmed   Journal   ReadQx 

Unusual White Esophageal Patches with Cobblestone Appearance.

Pubmed   Journal   ReadQx 

Gut

Adherent invasive Escherichia coli in Crohn's disease: guilt by association?

Pubmed   Journal   ReadQx 

Inflamm Bowel Dis

Pulmonary Infection Due to Reactivation of Latent Epstein-Barr Virus in a Patient With Crohn's Disease Treated With Infliximab.

Pubmed   Journal   ReadQx 

J Hepatol

Surgical treatment of intrahepatic cholangiocarcinoma.

Pubmed   Journal   ReadQx